Supersaturation is the driving force behind every crystallisation process. Control it well, and you control nucleation, growth, crystal size distribution, yield, and product quality. Lose control, and you invite variability, fines, agglomeration, and batch‑to‑batch inconsistency.
Clairet Scientific helps organisations achieve real‑time, closed‑loop supersaturation control using advanced spectroscopic PAT tools — enabling crystallisation processes that are measurable, stable, and scalable.
Why Supersaturation Control Matters
Supersaturation determines:
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When crystals form (nucleation)
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How fast they grow
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How many crystals appear
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Final crystal size distribution (CSD)
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Product purity and morphology
Traditional crystallisation relies on pre‑programmed cooling curves or empirical recipes. But real systems rarely behave ideally. Heat transfer varies, solubility shifts, and kinetics change with scale.
Modern PAT‑enabled supersaturation control replaces guesswork with direct measurement and feedback.
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Raman
Measures solute concentration. Tracks polymorph transitions, hydrates, solvates, and solid‑phase composition — essential when supersaturation drives form changes.
ATR‑FTIR
ATR‑FTIR measures solute concentration in situ, even in complex solutions
UV‑Vis
Fast concentration measurement in clear solutions; temperature‑corrected models (e.g., LSS) improve accuracy.
Together, these tools allow Clairet to design holistic crystallisation control strategies.
NIR
Provides combined solution + solid information, ideal for dissolution and precipitation behaviour.
Benefits of PAT‑Driven Supersaturation Control
✔ Higher product consistency
✔ Better control of nucleation and growth
✔ Improved crystal size distribution
✔ Reduced batch failures
✔ Faster development and scale‑up
✔ Real‑time visibility into process behaviour
Why Clairet Scientific?
Clairet provides:
Instrumentation
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Raman and THz Raman
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ATR-FTIR
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UV‑Vis systems
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NIR systems
Integration
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Probe installation
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Real‑time data acquisition
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Chemometric model development
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“Closed-loop control of supersaturation based on spectroscopy enables production of crystals with desired particle properties.”