PAT Spectroscopy for Crystallisation
Real‑time insight. Real‑time control. Real‑time confidence.
Crystallisation is one of the most critical steps in pharmaceutical and fine‑chemical manufacturing — and one of the most complex. PAT spectroscopy gives you real‑time visibility into concentration, supersaturation, polymorphs and crystallinity, enabling precise control and faster, more reliable scale‑up. Clairet Scientific provides the full suite of Raman, THz‑Raman, NIR, ATR‑FTIR and UV‑Vis solutions to make crystallisation predictable, measurable and robust.
Why PAT for Crystallisation?
- No sampling — measure directly in slurries and opaque media
- No delays — instant feedback for faster decisions
- No surprises — track polymorphs, hydrates, solvates and crystallinity in real time
- Better control — optimise nucleation, growth and supersaturation
The Spectroscopy Toolkit
Raman Polymorph identification, hydrate/anhydrate transitions, slurry monitoring. Sharp peaks, fast kinetics, ideal for polymorph control.
THz‑Raman Ultra‑sensitive crystallinity measurement (~1% w/w). Perfect for formulations, stability studies and final product QC.
UV‑Vis : Fast, simple concentration monitoring in clear solutions. Ideal for solubility curves and early process screening
ATR‑FTIR Direct concentration and supersaturation measurement. Enables closed‑loop cooling control and uniform crystal size
NIR Solution + solid information in one spectrum. Great for dissolution, precipitation and early‑stage development..
Transform Your Crystallisation Process
With PAT Spectroscopy you can:
- Maintain constant supersaturation for uniform crystals
- Track polymorph transitions as they occur
- Quantify crystalline/amorphous ratio
- Understand solid–liquid dynamics in real time
- Build robust, scalable crystallisation processes
Why Clairet Scientific?
We supply, integrate and support the full PAT ecosystem:
- Raman & THz‑Raman systems
- NIR and UV‑Vis platforms
- ATR‑FTIR for supersaturation control
- Probe installation, chemometrics, model building
From development to scale‑up, Clairet helps you make crystallisation predictable, controllable and commercially robust.
Book a Consultation Discuss your crystallisation challenges and explore tailored PAT strategies for development, scale‑up or manufacturing